NGM Open Innovation would be interested in hearing from researchers involved in the investigation of the underlying mechanisms of metabolic dysfunction. We are particularly interested in how metabolism and specifically energy homeostasis (including mitochondrial dysfunction) in the brain impacts upon the incidence and progression of neurodegenerative diseases.
Metabolic syndrome is a disorder of energy utilization and storage usually associated with obesity and subsequently, increased risk of developing cardiovascular and liver disease, and diabetes. Similarly, life-style choices (for example, caloric intake and physical exercise) and metabolic dysregulation have been linked to an increase in the incidence of certain neurodegenerative disorders (including Alzheimer’s, Parkinson’s and Huntington’s diseases).
Signalling pathways that regulate systemic metabolic factors are thus emerging as potential therapeutic targets for neurodegenerative disease therapeutics. In addition to these systemic factors, the brain itself is subject to an age-related decline in energy metabolism that is exacerbated in neurodegenerative disease. Mitochondria are central to the maintenance of energy homeostasis and redox status in all cells and are therefore vital for normal functioning and survival. Given the limited regenerative capacity of adult neurons in the brain, mitochondrial dysfunction and associated signalling pathways have become a key focus of research into neurodegenerative disease and opportunities to identify new therapeutics.
If you would like to discuss opportunities to work with NGM Open Innovation in this area please contact us at firstname.lastname@example.org